STATEWIDE KETAMINE THERAPY

Ketamine therapy for treatment-resistant depression in Florida.

Medically supervised ketamine sessions for adults with treatment-resistant depression, PTSD, and severe anxiety. Evaluated, administered, and monitored from start to finish by our board-certified providers at our Wesley Chapel clinic.

Accepting New Patients · In-Person + Statewide Telehealth
STATEWIDE KETAMINE THERAPY

Ketamine therapy for treatment-resistant depression.

Free 15-minute consult. We will match you with the right provider and get you on the calendar - usually within one business day.

0/500
Or call directly: (813) 670-3005
Your information is kept confidential.
Comfortable in-office ketamine therapy room at Ascend Mind and Body, Wesley Chapel.
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For when standard care hasn't worked.

Ketamine therapy that respects the science.

You've probably already done the research. You've read about response rates, looked up clinics, and weighed whether the cost is worth it. If you've tried two or more antidepressants without adequate relief and you're still struggling, ketamine therapy is a treatment option worth discussing with a provider who knows the research and will be straight with you about what it can and can't do.

Ketamine is a Schedule III controlled substance and, we believe, should be administered only under medical supervision. Off-label use for depression, PTSD, anxiety, and pain. Individual responses vary - there is no guarantee of response.

2 Hour Sessions Check-in, administration, and supervised recovery - every visit
6 Session Induction Standard protocol over 2–3 weeks, with maintenance as needed
1 Provider · Start to Finish Your provider evaluates, administers, and follows up - no hand-offs, ever
Ascend Mind and Body's ketamine treatment room - quiet, dimly lit, recliner-based Real treatment room · Wesley Chapel
The evaluation-first approach

An evaluation-first clinic.

Ketamine therapy at Ascend begins with a full psychiatric evaluation - no exceptions. Before any treatment is scheduled, your provider reviews your diagnostic history, prior medication trials, and clinical trajectory. The evaluation determines whether ketamine is appropriate for you - and if it isn't, you'll hear that clearly, along with alternatives worth exploring.

Because ketamine treatment at Ascend is integrated with our psychiatry practice, your provider can coordinate directly if your broader psychiatric plan needs adjustment - no external referral required.

How it works

Three steps from evaluation to maintenance.

There is no shortcut. The evidence supports a structured induction series followed by maintenance based on individual response.

Step i.

Clinical evaluation.

Thorough psychiatric evaluation in-person or via telehealth. Your provider reviews your treatment history, symptoms, conditions, and medications. If ketamine isn't appropriate, we'll tell you that and discuss alternatives.

Step ii.

Induction series.

Six sessions over two to three weeks. Each session is approximately two hours total. Clients are required to have a ride home after ketamine therapy.

Step iii.

Maintenance & follow-up.

After induction, our board-certified providers will evaluate your response and set a maintenance schedule if needed.

By evaluation only · not first-line

Conditions evaluated for ketamine treatment.

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Treatment-Resistant Depression (TRD)

The primary indication. Defined as failure to respond adequately to two or more antidepressant medications at therapeutic doses.

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02

Major Depressive Disorder (MDD)

Major depressive disorder not responsive to standard antidepressants, evaluated case by case as an adjunctive option coordinated with your broader psychiatric plan.

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Post-Traumatic Stress Disorder (PTSD)

When standard treatments - including trauma-focused therapy and first-line medications - have not produced sufficient relief. Ketamine for PTSD is used off-label.

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Severe Anxiety Disorders

Treatment-resistant anxiety that hasn't responded to standard pharmacological and therapeutic approaches. Evaluated case by case - not all anxiety presentations are appropriate candidates.

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05

Obsessive-Compulsive Disorder (OCD)

OCD that has not responded to first-line therapy and medication trials. Ketamine for OCD is used off-label and evaluated individually during your psychiatric consultation.

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06

Suicidal Ideation

Evaluated in appropriate clinical context. If you are in crisis, call or text 988 for the Suicide and Crisis Lifeline. Ketamine is not an emergency intervention.

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07

Bipolar Depression

Considered when medication adjustments alone have not produced adequate relief. Evaluated individually - bipolar presentations require careful clinical assessment before ketamine is considered.

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Chronic Pain Conditions

Adjunct, off-label use. Conditions such as CRPS and neuropathic pain evaluated individually. Clinical appropriateness is determined during your psychiatric evaluation.

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Every ketamine patient is evaluated first

Meet our providers.

Our board-certified providers handle ketamine evaluations, administration, and follow-up personally - start to finish. Meet the team at our Wesley Chapel clinic before you book.

Meet Our Providers Schedule a Consultation
Clinical disclosures

Honest disclosures.

Call us to discuss whether ketamine is appropriate for your situation, and to review pricing and financing options.

Clinical Disclosures

Important

Off-label use: Racemic ketamine is used off-label for depression, PTSD, anxiety, and pain. It is not FDA-approved for these uses.

Controlled substance: Ketamine is a Schedule III controlled substance and is administered only under medical supervision at our Wesley Chapel clinic.

Individual responses vary: Clinical studies suggest ketamine may produce improvement in depressive symptoms in some patients. Not all patients respond. There is no guarantee of response.

Common questions

Frequently asked questions.

What does a ketamine session actually feel like?

Most patients describe the experience during the session as a dreamlike or dissociative state. Some feel a sense of floating or detachment. Others experience mild visual changes. The effects wear off within 1 to 2 hours after the session. You'll be monitored the entire time and won't be left alone.

How soon might I notice a change?

Some patients report changes in mood or outlook after the first session. Others need the full induction series before noticing meaningful shifts. There's no guarantee of response, and your provider will check in with you after every session to assess how things are tracking.

Is ketamine addictive?

Ketamine has potential for misuse, which is why it's classified as a Schedule III controlled substance. In a supervised clinical setting with medical monitoring and structured dosing, the risk is managed. Your provider screens for substance use history during the evaluation and monitors patients throughout treatment.

Is ketamine FDA-approved for depression?

Racemic ketamine is used off-label for depression, PTSD, anxiety, and pain. It is not FDA-approved for these indications. Your provider will discuss the evidence, the risks, and the alternatives during your evaluation.

What happens if I miss a session during the induction?

Missing one session usually doesn't derail the series, but gaps can reduce effectiveness. If you need to reschedule, call as soon as possible so the clinical team can adjust your protocol. Consistency matters most during the induction phase.

Can I eat or drink before a session?

You'll receive specific instructions before your first session. Generally, patients are asked to avoid heavy meals for a few hours before treatment to reduce the chance of nausea. Light snacks are usually fine. No alcohol or recreational substances for at least 24 hours before.

If you or someone you know is in crisis: Call or text 988 for the Suicide and Crisis Lifeline. If this is an emergency, call 911 or go to your nearest emergency room.
Consultation by Appointment

Find out if ketamine therapy is right for you.

Schedule a consultation with a board-certified provider. We'll review your history, answer your questions, and give you a straight answer about whether ketamine makes sense for your situation.

Schedule a Consultation (813) 670-3005

Ketamine is a Schedule III controlled substance and, we believe, should be administered only under medical supervision.

Ketamine therapy in Tampa Bay: city routing

Ketamine therapy is delivered in-person at our Wesley Chapel clinic only. The city pages below cover eligibility, what to expect, and the routing path from your area to the Wesley Chapel suite. Telehealth screening is available statewide before in-person sessions begin.

Clinical references

  1. Murrough JW, Iosifescu DV, Chang LC, et al. Antidepressant efficacy of ketamine in treatment-resistant major depression: a two-site randomized controlled trial. American Journal of Psychiatry. 2013;170(10):1134-1142. doi:10.1176/appi.ajp.2013.13030392. PMID: 23982301.
  2. Wilkinson ST, Wright D, Fasula MK, et al. Cognitive behavior therapy may sustain antidepressant effects of intravenous ketamine in treatment-resistant depression. American Journal of Psychiatry. 2018;175(2):150-158. doi:10.1176/appi.ajp.2017.17040472.
  3. National Institute of Mental Health. Depression. nimh.nih.gov/health/topics/depression.
  4. U.S. Food and Drug Administration. Spravato (esketamine) is FDA-approved for treatment-resistant depression. Racemic ketamine for psychiatric indications is prescribed off-label, within the standard of care. Prescribing information via FDA Drugs@FDA.

Last medically reviewed by Anna Stouffer, PMHNP-BC on 2026-05-26.

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